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Journal article

Purine metabolism controls innate lymphoid cell function and protects against intestinal injury

Abstract:

Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the mechanisms through which purine metabolism modulates IBD remain to be established. Here, we found that mucosal expression of genes involved in the purine metabolic pathway is altered in patients with active ulcerative colitis (UC), which is a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imcb.12167

Authors


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Funding agency for:
Ho, GT
Grant:
MR/K013386/1
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Funding agency for:
Ruckerl, D
Grant:
MR/K013386/1
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Funding agency for:
Rossi, AG
Grant:
MR/K013386/1
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Funding agency for:
Anderton, SM
Grant:
MR/K013386/1
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Publisher:
Wiley Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
96
Issue:
10
Pages:
1049-1059
Publication date:
2018-05-14
Acceptance date:
2018-05-07
DOI:
ISSN:
0818-9641 and 1440-1711
Source identifiers:
894291
Keywords:
Pubs id:
pubs:894291
UUID:
uuid:5be0e471-4436-49cb-b0d3-c85b601c51e2
Local pid:
pubs:894291
Deposit date:
2018-08-07

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