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Epidemiological data and genome sequencing reveals that nosocomial transmission of SARS-CoV-2 is underestimated and mostly mediated by a small number of highly infectious individuals

Abstract:

Objectives: Despite robust efforts, patients and staff acquire SARS-CoV-2 infection in hospitals. We investigated whether whole-genome sequencing enhanced the epidemiological investigation of healthcare-associated SARS-CoV-2 acquisition. Methods: From 17-November-2020 to 5-January-2021, 803 inpatients and 329 staff were diagnosed with SARS-CoV-2 infection at four Oxfordshire hospitals. We classified cases using epidemiological definitions, looked for a potential source for each nosocomial inf...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jinf.2021.07.034

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-6825-9324
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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Infection Journal website
Volume:
83
Issue:
4
Pages:
473-482
Publication date:
2021-07-27
Acceptance date:
2021-07-24
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
Pmid:
34332019
Language:
English
Keywords:
Pubs id:
1188884
Local pid:
pubs:1188884
Deposit date:
2021-09-01

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