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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

Abstract:

Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their electrophysiological and secretory properties. Here, we monitored parameters that constitute the glucose-triggering pathway of insulin release. Both cell lines respond to glucose (6 and 20 mM) with 2- to 3-fold stimulation of insulin secretion which correlated with an elevatio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-34743-7

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0003-1244-7857
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More from this funder
Funding agency for:
Rorsman, P
Grant:
MR/L020149/1
More from this funder
Funding agency for:
Gloyn, A
Rorsman, P
Grant:
MR/L020149/1
MR/L020149/1
More from this funder
Funding agency for:
Gloyn, A
Grant:
MR/L020149/1
More from this funder
Funding agency for:
Gloyn, A
Rorsman, P
Grant:
MR/L020149/1
MR/L020149/1
More from this funder
Funding agency for:
Gloyn, A
Rorsman, P
Grant:
MR/L020149/1
MR/L020149/1
200837
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Issue:
1
Pages:
16994
Publication date:
2018-11-19
Acceptance date:
2018-10-19
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
30451893
Language:
English
Keywords:
Pubs id:
pubs:945344
UUID:
uuid:5a39d112-8429-4cac-92fd-d863993e63a1
Local pid:
pubs:945344
Source identifiers:
945344
Deposit date:
2018-12-06

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