Journal article
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
- Abstract:
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Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their electrophysiological and secretory properties. Here, we monitored parameters that constitute the glucose-triggering pathway of insulin release. Both cell lines respond to glucose (6 and 20 mM) with 2- to 3-fold stimulation of insulin secretion which correlated with an elevatio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.3MB)
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- Publisher copy:
- 10.1038/s41598-018-34743-7
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Authors
Funding
+ National Institute for Health Research
More from this funder
Funding agency for:
Gloyn, A
Grant:
MR/L020149/1
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Issue:
- 1
- Pages:
- 16994
- Publication date:
- 2018-11-19
- Acceptance date:
- 2018-10-19
- DOI:
- EISSN:
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2045-2322
- ISSN:
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2045-2322
- Pmid:
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30451893
- Source identifiers:
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945344
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:945344
- UUID:
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uuid:5a39d112-8429-4cac-92fd-d863993e63a1
- Local pid:
- pubs:945344
- Deposit date:
- 2018-12-06
Terms of use
- Copyright holder:
- Hastoy et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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