Working paper icon

Working paper

A novel inhibitor of complement C5 provides structural insights into activation

Abstract:

Abstract The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a novel class of inhibitors from tick saliva, the CirpT family, and generated detailed structural data revealing their mechanism of action. We show direct binding of a CirpT to complement C5 and have determined the structure o...

Expand abstract
Publication status:
Not published
Peer review status:
Reviewed (other)

Actions


Access Document


Publisher copy:
10.1101/647354

Authors


Expand authors...
Series:
bioRxiv
Publication date:
2019-05-23
DOI:
Source identifiers:
1023342
Keywords:
Pubs id:
pubs:1023342
UUID:
uuid:5a13c1d8-2c3c-4d74-adb8-4391608c67ae
Local pid:
pubs:1023342
Deposit date:
2019-07-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP