Working paper
A novel inhibitor of complement C5 provides structural insights into activation
- Abstract:
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Abstract The complement system is a crucial part of innate immune defences against invading pathogens. The blood-meal of the tick Rhipicephalus pulchellus lasts for days, and the tick must therefore rely on inhibitors to counter complement activation. We have identified a novel class of inhibitors from tick saliva, the CirpT family, and generated detailed structural data revealing their mechanism of action. We show direct binding of a CirpT to complement C5 and have determined the structure o...
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- Publication status:
- Not published
- Peer review status:
- Reviewed (other)
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Bibliographic Details
- Series:
- bioRxiv
- Publication date:
- 2019-05-23
- DOI:
- Source identifiers:
-
1023342
Item Description
- Keywords:
- Pubs id:
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pubs:1023342
- UUID:
-
uuid:5a13c1d8-2c3c-4d74-adb8-4391608c67ae
- Local pid:
- pubs:1023342
- Deposit date:
- 2019-07-18
Terms of use
- Copyright holder:
- Reichhardt et al
- Copyright date:
- 2019
- Notes:
- © The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. This is a pre-print version of the paper.
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