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Journal article

Molecular diagnosis of orthopaedic device infection direct from sonication fluid by metagenomic sequencing.

Abstract:

Culture of multiple periprosthetic tissue samples is the current gold-standard for microbiological diagnosis of prosthetic joint infections (PJI). Additional diagnostic information may be obtained through sonication fluid culture of explants. However, current techniques can have relatively low sensitivity, with prior antimicrobial therapy and infection by fastidious organisms influencing results. We assessed if metagenomic sequencing of total DNA extracts obtained direct from sonication fluid...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JCM.00462-17

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Peto, T
Grant:
Senior Investigator
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Funding agency for:
Crook, D
Grant:
Senior Investigator
More from this funder
Funding agency for:
Eyre, D
Grant:
Clinical Lecturer
National Institute for Health Research More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Volume:
55
Issue:
8
Pages:
2334-2347
Publication date:
2017-05-01
Acceptance date:
2017-05-08
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Source identifiers:
695822
Language:
English
Keywords:
Pubs id:
pubs:695822
UUID:
uuid:59c529a9-5849-43ba-8f89-1b405fa9bcdf
Local pid:
pubs:695822
Deposit date:
2017-06-07

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