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Journal article

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

Abstract:

MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT cells. TCR-independent activation of these MAIT cells from blood and gut was maximized by extending the panel of cytokines to include TNF-superfamily member TL1A. RNA-seq experiments revealed that TCR-dependent and TCR-independent signals drive MAIT cells ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2019.08.050

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Institution:
University of Oxford
Department:
NDM
Role:
Author
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Institution:
University of Oxford
Department:
NDM
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
28
Issue:
12
Pages:
3077-3091
Publication date:
2019-09-17
Acceptance date:
2019-08-16
DOI:
ISSN:
2211-1247
Source identifiers:
1046086
Language:
English
Keywords:
Pubs id:
pubs:1046086
UUID:
uuid:598481fe-f6da-40e2-81d3-2236e1398658
Local pid:
pubs:1046086
Deposit date:
2019-08-19

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