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The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast

Abstract:

Previously we reported that a process called inter-fork strand annealing (IFSA) causes genomic deletions during the termination of DNA replication when an active replication fork converges on a collapsed fork (Morrow et al., 2017). We also identified the FANCM-related DNA helicase Fml1 as a potential suppressor of IFSA. Here, we confirm that Fml1 does indeed suppress IFSA, and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf2 via its C-terminal d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
8
Article number:
e49784
Publication date:
2019-12-19
Acceptance date:
2019-12-18
DOI:
EISSN:
2050-084X
Pubs id:
pubs:1078361
UUID:
uuid:587f4c15-20d2-46c7-8136-bf47db44341f
Source identifiers:
1078361
Local pid:
pubs:1078361
Language:
English
Keywords:

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