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Journal article

A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime - MVA85A boost in healthy UK adults

Abstract:

BACKGROUND: This phase I trial evaluated the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime-MVA85A boost, previously demonstrated to be protective in animal studies, in healthy UK adults.

METHODS: We enrolled 42 healthy, BCG-vaccinated adults into 4 groups: low dose Starter Group (n = 6; ChAdOx1 85A alone), high dose groups; Group A (n = 12; ChAdOx1 85A), Group B (n = 12; ChAdOx1 85A prime - MVA85A boost...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2019.10.102

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Institution:
University of Oxford
Department:
NDM
Sub department:
Jenner Institute
Oxford college:
Green Templeton College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
38
Issue:
2020
Pages:
779-789
Publication date:
2019-11-15
Acceptance date:
2019-10-31
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pmid:
31735500
Source identifiers:
1073096
Language:
English
Keywords:
Pubs id:
pubs:1073096
UUID:
uuid:5869a47f-58c4-4222-b1e2-beefd7e168f6
Local pid:
pubs:1073096
Deposit date:
2019-11-26

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