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Journal article

Genetic and real-world clinical data, combined with empirical validation, nominate Jak-Stat signaling as a target for Alzheimer’s disease therapeutic development

Abstract:

As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly increased. Despite this increase in the number of single-nucleotide polymorphisms (SNPs) identified per disease, their biological interpretation has in many cases remained elusive. To address this, we have combined GWAS results with orthogonal sources of evidence, namely the current knowledge of molecular pathways; real-world clinical data from...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/cells8050425

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-9276-2720
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
ORCID:
0000-0003-2854-2576
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Publisher:
MDPI Publisher's website
Journal:
Cells Journal website
Volume:
8
Issue:
5
Article number:
425
Publication date:
2019-05-08
Acceptance date:
2019-05-01
DOI:
EISSN:
2073-4409
Pmid:
31072055
Source identifiers:
999454
Language:
English
Keywords:
Pubs id:
pubs:999454
UUID:
uuid:58066f1a-da90-4cba-90ae-958bde477bbb
Local pid:
pubs:999454
Deposit date:
2019-05-28

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