Journal article
Genetic and real-world clinical data, combined with empirical validation, nominate Jak-Stat signaling as a target for Alzheimer’s disease therapeutic development
- Abstract:
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As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly increased. Despite this increase in the number of single-nucleotide polymorphisms (SNPs) identified per disease, their biological interpretation has in many cases remained elusive. To address this, we have combined GWAS results with orthogonal sources of evidence, namely the current knowledge of molecular pathways; real-world clinical data from...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.6MB)
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- Publisher copy:
- 10.3390/cells8050425
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Authors
Funding
Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Cells Journal website
- Volume:
- 8
- Issue:
- 5
- Article number:
- 425
- Publication date:
- 2019-05-08
- Acceptance date:
- 2019-05-01
- DOI:
- EISSN:
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2073-4409
- Pmid:
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31072055
- Source identifiers:
-
999454
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:999454
- UUID:
-
uuid:58066f1a-da90-4cba-90ae-958bde477bbb
- Local pid:
- pubs:999454
- Deposit date:
- 2019-05-28
Terms of use
- Copyright holder:
- Nevado-Holgado et al
- Copyright date:
- 2019
- Notes:
- © The Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
- Licence:
- CC Attribution (CC BY)
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