Journal article icon

Journal article

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Abstract:

Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog tick saliva contains polyvalent CC-chemokine binding peptides termed evasins 1 and 4, that efficiently disrupt the chemokine network in models of inflammatory disease. Here we develop yeast surface display as a tool for functionally identifyi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41598-017-04378-1

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Alenazi, Y
Grant:
Studentship
More from this funder
Funding agency for:
Eaton, J
Grant:
Studentship
More from this funder
Funding agency for:
Kawamura, A
Grant:
Dorothy Hodgkin Fellowship
More from this funder
Funding agency for:
Bhattacharya, S
Grant:
CH/09/003
British Heart Foundation More from this funder
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Sci Rep Journal website
Volume:
7
Publication date:
2017-06-27
Acceptance date:
2017-05-31
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:702254
UUID:
uuid:576dce24-65ea-4653-ba9e-64cf13c8bbb8
Local pid:
pubs:702254
Deposit date:
2017-07-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP