Journal article
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
- Abstract:
-
Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory disease. Dog tick saliva contains polyvalent CC-chemokine binding peptides termed evasins 1 and 4, that efficiently disrupt the chemokine network in models of inflammatory disease. Here we develop yeast surface display as a tool for functionally identifyi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Royal Society
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Funding agency for:
Kawamura, A
Grant:
Dorothy Hodgkin Fellowship
+ British Heart Foundation
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Funding agency for:
Eaton, J
Bhattacharya, S
Grant:
Studentship
CH/09/003
+ Saudi Arabian Cultural Bureau
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Funding agency for:
Alenazi, Y
Grant:
Studentship
Wellcome Trust
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University of Oxford
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Sci Rep Journal website
- Volume:
- 7
- Publication date:
- 2017-06-27
- Acceptance date:
- 2017-05-31
- DOI:
- ISSN:
-
2045-2322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:702254
- UUID:
-
uuid:576dce24-65ea-4653-ba9e-64cf13c8bbb8
- Local pid:
- pubs:702254
- Deposit date:
- 2017-07-10
Terms of use
- Copyright holder:
- Singh et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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