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Homozygosity and risk of childhood death due to invasive bacterial disease

Abstract:

Background: Genetic heterozygosity is increasingly being shown to be a key predictor of fitness in natural populations, both through inbreeding depression, inbred individuals having low heterozygosity, and also through chance linkage between a marker and a gene under balancing selection. One important component of fitness that is often highlighted is resistance to parasites and other pathogens. However, the significance of equivalent loci in human populations remains unclear. Consequently, we...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2350-10-55

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
"University of Cambridge"
Department:
Department of Zoology
Role:
Author
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Institution:
"Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
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Institution:
"University of Cambridge"
Department:
Department of Zoology
Role:
Author
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Institution:
"Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
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Funding agency for:
Hill, A
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medical Genetics Journal website
Volume:
10
Article number:
55
Publication date:
2009-06-01
DOI:
ISSN:
1471-2350
Language:
English
Subjects:
UUID:
uuid:575b1e31-54bc-4a88-b9ad-b376d4859e1a
Local pid:
ora:3082
Deposit date:
2009-11-25

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