Journal article
Fluid dynamic characterization of a fluidized‐bed perfusion bioreactor with CFD–DEM simulation
- Abstract:
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BACKGROUND: In the recent development of regenerative medicine, the low yields of progenitor cells have limited the large-scale clinical applications. To overcome the limitation, a novel fluidized bed bioreactor has emerged. However, a detailed understanding of the fluid dynamics is still lacking.
RESULTS: A three-dimensional modelling approach that couples computational fluid dynamics (CFD) and discrete element method (DEM) was used to simulate the liquid and solid f...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.8MB)
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- Publisher copy:
- 10.1002/jctb.5576
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Authors
Funding
China Regenerative Medicine International
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Chemical Technology and Biotechnology Journal website
- Volume:
- 93
- Issue:
- 8
- Pages:
- 2316-2330
- Publication date:
- 2018-01-09
- Acceptance date:
- 2018-01-04
- DOI:
- EISSN:
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1097-4660
- ISSN:
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0268-2575
- Source identifiers:
-
820634
Item Description
- Keywords:
- Pubs id:
-
pubs:820634
- UUID:
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uuid:56b4efca-4619-41c5-8cb7-9bbf25cc95ec
- Local pid:
- pubs:820634
- Deposit date:
- 2018-01-19
Terms of use
- Copyright holder:
- Society of Chemical Industry
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Society of Chemical Industry. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/jctb.5576
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