Journal article
Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging
- Abstract:
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Background
A lack of objective outcome measures and overreliance on subjective pain reports in early proof-of-concept studies contribute to the high attrition of potentially effective new analgesics. We studied the utility of neuroimaging in providing objective evidence of neural activity related to drug modulation or a placebo effect in a double-blind, randomized, placebo-controlled, three-way crossover trial.Methods
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We chronically adminis...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1016/j.bja.2017.11.064
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Authors
Funding
NIHR Oxford Biomedical Research Centre
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Pfizer
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Medical Research Council
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- British Journal of Anaesthesia Journal website
- Volume:
- 120
- Issue:
- 2
- Pages:
- 299–307
- Publication date:
- 2018-02-07
- Acceptance date:
- 2017-08-07
- DOI:
Item Description
- Keywords:
- Pubs id:
-
pubs:823052
- UUID:
-
uuid:56b1308f-5942-4569-bc3f-f2a493a681c0
- Local pid:
- pubs:823052
- Deposit date:
- 2018-02-07
Terms of use
- Copyright holder:
- Wanigasekera et al
- Copyright date:
- 2018
- Notes:
- © 2017 Published by Elsevier Ltd on behalf of British Journal of Anaesthesia. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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