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Thesis

The role of autophagy in mature adipocytes during homeostasis and intestinal inflammation

Abstract:

Autophagy is an evolutionary conserved lysosomal degradation pathway, which can control cell-intrinsic functions such as di erentiation and cellular metabolism. The cell-intrinsic role of autophagy is of particular importance to immune cells, but autophagy also has a cell-extrinsic role in the tumour environment. It remains unclear whether autophagy in the tissue environment can alter immune responses. The release of free fatty acids (FFA) from adipocytes in times of high energy demands (e...

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Authors


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Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Research group:
Anna Katharina Simon
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-3415-3449

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
Wolfson College
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
St Edmund Hall
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
Wolfson College
Role:
Supervisor
More from this funder
Programme:
Infection, Immunity and Translational Medicine (IITM) DPhil Program
Funding agency for:
Richter, FC
Grant:
203803/Z16/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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