Thesis
Exon skipping peptide-pmos for correction of dystrophin in mouse models of duchenne muscular dystrophy
- Abstract:
-
Duchenne muscular dystrophy (DMD) is a fatal, muscle-wasting disorder due to mutations/deletions in the dystrophin gene. Whilst improvements in palliative care have increased the life expectancy of patients, cardiomyopathy and respiratory complications are still the leading causes of death. A potential therapy for the treatment of DMD is antisense oligonucleotides (AOs), which modulate dystrophin pre-mRNA splicing to restore the dystrophin reading frame and generate a truncated functional ...
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Authors
Contributors
+ Wood, M
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
+ Hammond, S
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:545d586a-ad7b-4089-8537-b2677957b874
- Local pid:
- ora:9894
- Deposit date:
- 2015-02-03
Terms of use
- Copyright holder:
- Corinne Betts
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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