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The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma.

Abstract:

The use of oral methotrexate for refractory eosinophilic asthma in a tertiary asthma referral centre, Glenfield Hospital, Leicester, was evaluated between January 2006 and December 2014. The patients ( n = 61) were carefully phenotyped at baseline with markers of airway inflammation. In addition, a structured oral methotrexate proforma was utilized to evaluate response to therapy and adverse events. Oral steroid withdrawal was attempted 3 months after commencing treatment. Several outcomes we...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1479972317709650

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Institution:
University of Oxford
Oxford college:
St Edmund Hall
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
SAGE Publications Publisher's website
Journal:
Chronic Respiratory Disease Journal website
Publication date:
2017-06-01
Acceptance date:
2017-03-21
DOI:
ISSN:
1479-9731
Source identifiers:
700939
Language:
English
Keywords:
Pubs id:
pubs:700939
UUID:
uuid:54520e33-ab20-49e9-89a6-2de5ebd3f5f1
Local pid:
pubs:700939
Deposit date:
2017-07-13

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