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Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases

Abstract:

Obesity is associated with changes in the secretome of adipose tissue (AT), which affects the vasculature through endocrine and paracrine mechanisms. Wingless-related integration site 5A (WNT5A) and secreted frizzled-related protein 5 (SFRP5), adipokines that regulate noncanonical Wnt signaling, are dysregulated in obesity. We hypothesized that WNT5A released from AT exerts endocrine and paracrine effects on the arterial wall through noncanonical RAC1-mediated Wnt signaling. In a cohort of 10...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scitranslmed.aav5055

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Oxford college:
Trinity College
Role:
Author
ORCID:
0000-0002-4674-0210
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
11
Issue:
510
Article number:
aav5055
Publication date:
2019-09-18
Acceptance date:
2019-08-09
DOI:
ISSN:
1946-6234
Source identifiers:
1053008
Keywords:
Pubs id:
pubs:1053008
UUID:
uuid:542351b0-9a55-4f64-9350-98e17622617c
Local pid:
pubs:1053008
Deposit date:
2019-09-11

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