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Journal article

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionizing radiation and complex DNA damage

Abstract:

Purpose:
Ionizing radiation, particular high-linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) wherein 2 or more DNA lesions are induced in close proximity, which contributes significantly to the cell killing effects. However, knowledge of the enzymes and mechanisms involved in coordinating the recognition and processing of CDD in cellular DNA are currently lacking.


Methods and Materials:
A small interfering ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ijrobp.2019.02.053

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Wolfson College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology - Biology - Physics Journal website
Volume:
104
Issue:
3
Pages:
656-665
Publication date:
2019-03-07
Acceptance date:
2019-02-26
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Pmid:
30851349
Source identifiers:
983975
Language:
English
Pubs id:
pubs:983975
UUID:
uuid:53fb6930-93c1-4ce0-874b-c7310e3220fe
Local pid:
pubs:983975
Deposit date:
2019-04-02

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