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Journal article

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Abstract:

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98(th) or <2(n...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajhg.2014.01.010

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Publisher:
Cell Press Publisher's website
Journal:
American journal of human genetics Journal website
Volume:
94
Issue:
2
Pages:
233-245
Publication date:
2014-02-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
449160

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