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A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity

Abstract:

Lung function is a heritable complex phenotype with obesity being one of its important risk factors. However, the knowledge of their shared genetic basis is limited. Most genome-wide association studies (GWASs) for lung function have been based on European populations, limiting the generalisability across populations. Large-scale lung function GWAS in other populations are lacking.

We included 100 285 subjects from China Kadoorie Biobank (CKB). To identify novel loci for lung funct...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1183/13993003.00199-2021

Authors


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Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0002-9179-0321
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Publisher:
European Respiratory Society Publisher's website
Journal:
European Respiratory Journal Journal website
Volume:
58
Issue:
3
Article number:
2100199
Publication date:
2021-03-25
Acceptance date:
2021-03-02
DOI:
EISSN:
1399-3003
ISSN:
0903-1936
Language:
English
Keywords:
Pubs id:
1166770
Local pid:
pubs:1166770
Deposit date:
2021-03-10

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