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Journal article

Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease

Abstract:

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic mesenchyme in these processes remains unknown. Using unbiased single-cell profiling of over 16,500 colonic mesenchymal cells, we reveal four subsets of fibroblasts expressing divergent transcriptional regulators and functional pathways, in addition to pericytes and myofibroblasts. We identified a niche population located...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2018.08.067

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-3247-3676
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Chen, H
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Funding agency for:
Fawkner-Corbett, D
Grant:
Research Fellowship
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Funding agency for:
Antanaviciute, A
More from this funder
Funding agency for:
Fawkner-Corbett, D
Grant:
Research Fellowship
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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
175
Issue:
2
Pages:
372-386.e17
Publication date:
2018-09-27
Acceptance date:
2018-08-29
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
30270042
Source identifiers:
923780
Language:
English
Keywords:
Pubs id:
pubs:923780
UUID:
uuid:526de786-416a-4252-bcf1-50f7ecca93fd
Local pid:
pubs:923780
Deposit date:
2018-11-09

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