Journal article
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
- Abstract:
-
Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic mesenchyme in these processes remains unknown. Using unbiased single-cell profiling of over 16,500 colonic mesenchymal cells, we reveal four subsets of fibroblasts expressing divergent transcriptional regulators and functional pathways, in addition to pericytes and myofibroblasts. We identified a niche population located...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Crohn’s and Colitis UK
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Funding agency for:
Simmons, A
Grant:
Investigator Award (102974/Z/13/Z)
+ National Institutes for Health Research
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Funding agency for:
Simmons, A
Grant:
Investigator Award (102974/Z/13/Z)
+ Medical Research Council
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Funding agency for:
Koohy, H
Simmons, A
Grant:
Investigator Award (102974/Z/13/Z)
+ Wellcome Trust
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Funding agency for:
Mellado-Gomez, E
Attar, M
Sharma, E
Bowden, R
Simmons, A
Grant:
Investigator Award (102974/Z/13/Z)
+ British Association of Paediatric Surgeons
More from this funder
Funding agency for:
Fawkner-Corbett, D
Grant:
Research Fellowship
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 175
- Issue:
- 2
- Pages:
- 372-386.e17
- Publication date:
- 2018-09-27
- Acceptance date:
- 2018-08-29
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pmid:
-
30270042
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:923780
- UUID:
-
uuid:526de786-416a-4252-bcf1-50f7ecca93fd
- Local pid:
- pubs:923780
- Source identifiers:
-
923780
- Deposit date:
- 2018-11-09
Terms of use
- Copyright holder:
- Kinchen et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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