Journal article icon

Journal article

Extracellular K+ dampens T cell functions: implications for immune suppression in the tumor microenvironment

Abstract:

Background: Dying tumor cells release intracellular potassium (K+), raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40–50 mM (high-[K+]e). Here, we investigated the effect of high-[K+]e on T cell functions.

Materials and Methods: Functional impacts of high-[K+]e ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1089/bioe.2019.0016

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Oxford college:
Wolfson College
Role:
Author
Expand authors...
Publisher:
Mary Ann Liebert Publisher's website
Journal:
Bioelectricity Journal website
Volume:
1
Issue:
3
Pages:
169-179
Publication date:
2019-09-05
Acceptance date:
2019-08-11
DOI:
EISSN:
2576-3113
ISSN:
2576-3105
Language:
English
Keywords:
Pubs id:
1136578
Local pid:
pubs:1136578
Deposit date:
2020-10-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP