Journal article
Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.
- Abstract:
-
Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent,...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature communications Journal website
- Volume:
- 7
- Pages:
- 10562
- Publication date:
- 2016-02-01
- Acceptance date:
- 2015-12-28
- DOI:
- EISSN:
-
2041-1723
- ISSN:
-
2041-1723
Item Description
- Language:
- English
- Pubs id:
-
pubs:609262
- UUID:
-
uuid:512354fa-bb2a-4feb-82c7-c20e96529b07
- Local pid:
- pubs:609262
- Source identifiers:
-
609262
- Deposit date:
- 2016-03-30
Terms of use
- Copyright holder:
- Dustin et al
- Copyright date:
- 2016
- Notes:
- © 2016 Dustin et al. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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