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Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.

Abstract:

Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms10562

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature communications Journal website
Volume:
7
Pages:
10562
Chapter number:
ARTN 10562
Publication date:
2016-02-05
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:512354fa-bb2a-4feb-82c7-c20e96529b07
Source identifiers:
609262
Local pid:
pubs:609262
Language:
English

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