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Journal article

Controlling protein orientation in vacuum using electric fields

Abstract:

Single-particle imaging using X-ray free-electron lasers is an emerging technique that could provide high-resolution structures of macromolecules in the gas phase. One of the largest difficulties in realizing this goal is the unknown orientation of the individual sample molecules at the time of exposure. Preorientation of the molecules has been identified as a possible solution to this problem. Using molecular dynamics simulations, we identify a range of electric field strengths where protein...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
  • (Accepted manuscript, pdf, 1.6MB)
  • (Accepted manuscript, pdf, 2.0MB)
Publisher copy:
10.1021/acs.jpclett.7b02005

Authors


More by this author
Institution:
University of Oxford
Oxford college:
University College
Role:
Author
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Physical Chemistry Letters Journal website
Volume:
8
Issue:
18
Pages:
4540–4544
Publication date:
2017-09-01
Acceptance date:
2017-09-01
DOI:
ISSN:
1948-7185
Pmid:
28862456
Source identifiers:
729003
Language:
English
Pubs id:
pubs:729003
UUID:
uuid:50818280-bd9f-4c99-aa94-ecd6e741c23e
Local pid:
pubs:729003
Deposit date:
2017-09-22

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