Thesis
Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S
- Abstract:
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Endoglycosidase (Endo) S, secreted by bacterial pathogen Streptococcus pyogenes, is an important immunomodulatory enzyme which specifically hydrolyses the functionally important N-linked complex biantennary glycan found at Asn297 on the CH2 domain of fragment crystallisable (Fc) on human immunoglobulin G (IgG). Deglycosylation of IgG Fc leads to complete loss of binding to cellular Fcγ receptors (FcγRs) thus abolishing antibody dependent cellular cytoxicity (ADCC)...
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Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Goodfellow, J
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:507ca9a6-7983-4565-8e19-c4372fd6ed78
- Local pid:
- ora:12142
- Deposit date:
- 2015-08-13
Terms of use
- Copyright holder:
- Jonathan J Goodfellow
- Copyright date:
- 2011
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