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Investigating the N-linked glycan specificity of bacterial endo-beta-N-acetylglucosaminidase S

Abstract:

Endoglycosidase (Endo) S, secreted by bacterial pathogen Streptococcus pyogenes, is an important immunomodulatory enzyme which specifically hydrolyses the functionally important N-linked complex biantennary glycan found at Asn297 on the CH2 domain of fragment crystallisable (Fc) on human immunoglobulin G (IgG). Deglycosylation of IgG Fc leads to complete loss of binding to cellular Fcγ receptors (FcγRs) thus abolishing antibody dependent cellular cytoxicity (ADCC)...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
BGD
Oxford college:
Oriel College
Role:
Author
More by this author
Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2011
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:507ca9a6-7983-4565-8e19-c4372fd6ed78
Local pid:
ora:12142
Deposit date:
2015-08-13

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