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ReN VM spheroids in matrix: A neural progenitor three-dimensional in vitro model reveals DYRK1A inhibitors as potential regulators of radio-sensitivity

Abstract:

Introduction Pre-clinical testing of small molecules for therapeutic development across many pathologies relies on the use of in-vitro and in-vivo models. When designed and implemented well, these models serve to predict the clinical outcome as well as the toxicity of the evaluated therapies. The two-dimensional (2D) reductionist approach where cells are incubated in a mono-layer on hard plastic microtiter plates is relatively inexpensive but not physiologically relevant. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbrc.2020.07.130

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
ORCID:
0000-0003-3600-7928
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0002-6894-7829
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-6495-7026
National Centre for the Replacement, Refinement and Reduction of Animals in Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biochemical and Biophysical Research Communications Journal website
Volume:
531
Issue:
4
Pages:
535-542
Publication date:
2020-08-14
Acceptance date:
2020-07-28
DOI:
EISSN:
1090-2104
ISSN:
1090-2104
Pmid:
32807492
Language:
English
Keywords:
Pubs id:
1127270
Local pid:
pubs:1127270
Deposit date:
2020-11-11

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