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Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.

Abstract:

Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor receptor. iRhoms, catalytically inactive members of the rhomboid-like superfamily, have been shown to control the ER-to-Golgi transport and maturation of TACE. Here, we reveal that iRhom2 remains associat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.23968

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Grieve, A
Grant:
659166
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Funding agency for:
Grieve, A
Grant:
659166
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Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
More from this funder
Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
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Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Publication date:
2017-04-01
Acceptance date:
2017-04-20
DOI:
EISSN:
2050-084X
Source identifiers:
691215
Pubs id:
pubs:691215
UUID:
uuid:4e9a8f38-28e6-4603-9745-e84de9aadbef
Local pid:
pubs:691215
Deposit date:
2017-04-26

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