Journal article
Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
- Abstract:
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Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating intercellular signalling. TACE is a major shedding protease, responsible for the liberation of the inflammatory cytokine TNFα and ligands of the epidermal growth factor receptor. iRhoms, catalytically inactive members of the rhomboid-like superfamily, have been shown to control the ER-to-Golgi transport and maturation of TACE. Here, we reveal that iRhom2 remains associat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 5.3MB)
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- Publisher copy:
- 10.7554/eLife.23968
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Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
+ Medical Research Council
More from this funder
Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
+ Boehringer Ingelheim Fonds
More from this funder
Funding agency for:
Künzel, U
Grant:
Graduate student scholarship
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Publication date:
- 2017-04-01
- Acceptance date:
- 2017-04-20
- DOI:
- EISSN:
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2050-084X
- Source identifiers:
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691215
Item Description
- Pubs id:
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pubs:691215
- UUID:
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uuid:4e9a8f38-28e6-4603-9745-e84de9aadbef
- Local pid:
- pubs:691215
- Deposit date:
- 2017-04-26
Terms of use
- Copyright holder:
- Grieve et al
- Copyright date:
- 2017
- Notes:
- © 2017, Grieve et al. This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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