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A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.

Abstract:

Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni.3058

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Immunology Journal website
Volume:
16
Issue:
2
Pages:
170–177
Publication date:
2014-12-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
499670
Language:
English
Pubs id:
pubs:499670
UUID:
uuid:4e9477c3-d320-44ea-99ba-3590fa33b505
Local pid:
pubs:499670
Deposit date:
2014-12-20

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