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N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

Abstract:

The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5 and N11 were mutated to a glutamine to generate NTCP with a single glycan (NTCP-N5Q or NTCP- N11Q) or no glycans (NTCP- N5,11Q). HepG2 cells expressing NTCP with a single glycan supported HBV infe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0170419

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
van de Graaf, S
Grant:
337479
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Funding agency for:
van de Graaf, S
Grant:
337479
German Excellence Initiative More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
1
Pages:
e0170419
Publication date:
2017-01-26
Acceptance date:
2017-01-04
DOI:
ISSN:
1932-6203
Source identifiers:
675247
Language:
English
Keywords:
Pubs id:
pubs:675247
UUID:
uuid:4d124d81-e539-4862-a0d3-50abc6b7ac91
Local pid:
pubs:675247
Deposit date:
2017-02-03

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