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Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer

Abstract:
Background Constitutional loss of function (LOF) single nucleotide polymorphisms (SNPs) in pattern recognition receptors FPR1, TLR3 and TLR4 have previously been reported to predict oxaliplatin benefit in colorectal cancer. Confirmation of this association could substantially improve patient stratification. Methods We performed a retrospective biomarker analysis of the SCOT and COIN/COIN-B trials. Participant status for LOF variants in FPR1 (rs867228), TLR3... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jnci/djy215

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Experimental Medicine
Oxford college:
Wadham College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Briggs, S
Grant:
Clinical Research Training Fellowship
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Funding agency for:
Church, D
Grant:
Academy of Medical Sciences Clinician Scientist Fellowship
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Grant:
Oxford NIHR Comprehensive Biomedical Research Centre
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Grant:
Seventh Framework Programme (FP7/207- 2013) grant 258236
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Publisher:
Oxford University Press Publisher's website
Journal:
JNCI: Journal of the National Cancer Institute Journal website
Volume:
111
Issue:
8
Pages:
828–836
Publication date:
2019-01-14
Acceptance date:
2018-10-05
DOI:
EISSN:
1460-2105
ISSN:
0027-8874

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