Journal article
Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein ib via AKT/glycogen synthase kinase-3/dynamin and integrin αiibβ3
- Abstract:
-
Objective— Platelet endothelial cell adhesion molecule-1 (PECAM-1) regulates platelet response to multiple agonists. How this immunoreceptor tyrosine-based inhibitory motif–containing receptor inhibits G protein-coupled receptor–mediated thrombin-induced activation of platelets is unknown.
Expand abstract
Approach and Results— Here, we show that the activation of PECAM-1 inhibits fibrinogen binding to integrin αIIbβ3 and P-selectin surface expression in res...
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1161/atvbaha.114.304097
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Authors
Funding
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
- Volume:
- 34
- Issue:
- 9
- Pages:
- 1968-1976
- Publication date:
- 2014-06-26
- Acceptance date:
- 2014-06-10
- DOI:
- EISSN:
-
1524-4636
- ISSN:
-
1079-5642
- Pmid:
-
24969778
- Source identifiers:
-
475181
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:475181
- UUID:
-
uuid:4c7be3b3-4281-4609-b02b-e828efe9746b
- Local pid:
- pubs:475181
- Deposit date:
- 2018-01-19
Terms of use
- Copyright holder:
- American Heart Association
- Copyright date:
- 2014
- Notes:
- © 2014 American Heart Association, Inc.
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