Journal article icon

Journal article

Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein ib via AKT/glycogen synthase kinase-3/dynamin and integrin αiibβ3

Abstract:

Objective— Platelet endothelial cell adhesion molecule-1 (PECAM-1) regulates platelet response to multiple agonists. How this immunoreceptor tyrosine-based inhibitory motif–containing receptor inhibits G protein-coupled receptor–mediated thrombin-induced activation of platelets is unknown.
Approach and Results— Here, we show that the activation of PECAM-1 inhibits fibrinogen binding to integrin αIIbβ3 and P-selectin surface expression in res...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1161/atvbaha.114.304097

Authors


More by this author
Role:
Author
ORCID:
0000-0001-7537-1509
More by this author
Role:
Author
ORCID:
0000-0002-6006-6517
Expand authors...
Publisher:
American Heart Association Publisher's website
Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
Volume:
34
Issue:
9
Pages:
1968-1976
Publication date:
2014-06-26
Acceptance date:
2014-06-10
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Pmid:
24969778
Source identifiers:
475181
Language:
English
Keywords:
Pubs id:
pubs:475181
UUID:
uuid:4c7be3b3-4281-4609-b02b-e828efe9746b
Local pid:
pubs:475181
Deposit date:
2018-01-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP