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Journal article

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation

Abstract:

Mucosal-associated invariant T (MAIT) cells are a well-characterized innate-like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T cell receptor, which recognizes microbial metabolites presented on MR1, and through cytokine-mediated triggering. Typically, they show a quiescent memory phenotype but can undergo rapid up-regulation of effector functions including cytolysis u...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imcb.12020

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Publisher:
John Wiley & Sons Australia, Ltd Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
96
Issue:
6
Pages:
666-674
Publication date:
2018-03-09
Acceptance date:
2018-02-04
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Pmid:
29423939
Source identifiers:
826157
Language:
English
Keywords:
Pubs id:
pubs:826157
UUID:
uuid:4c661ba8-884c-465d-9d28-7cfff098ce08
Local pid:
pubs:826157
Deposit date:
2018-02-24

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