Journal article
Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation
- Abstract:
-
Mucosal-associated invariant T (MAIT) cells are a well-characterized innate-like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T cell receptor, which recognizes microbial metabolites presented on MR1, and through cytokine-mediated triggering. Typically, they show a quiescent memory phenotype but can undergo rapid up-regulation of effector functions including cytolysis u...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 572.4KB)
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- Publisher copy:
- 10.1111/imcb.12020
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Authors
Funding
Bibliographic Details
- Publisher:
- John Wiley & Sons Australia, Ltd Publisher's website
- Journal:
- Immunology and Cell Biology Journal website
- Volume:
- 96
- Issue:
- 6
- Pages:
- 666-674
- Publication date:
- 2018-03-09
- Acceptance date:
- 2018-02-04
- DOI:
- EISSN:
-
1440-1711
- ISSN:
-
0818-9641
- Pmid:
-
29423939
- Source identifiers:
-
826157
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:826157
- UUID:
-
uuid:4c661ba8-884c-465d-9d28-7cfff098ce08
- Local pid:
- pubs:826157
- Deposit date:
- 2018-02-24
Terms of use
- Copyright holder:
- Zinser et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Immunology and Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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