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Journal article

Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency

Abstract:

Objective: On the basis of our previous work with triheptanoin, which provides key substrates to the Krebs cycle in the brain, we wished to assess its therapeutic effect in patients with glucose transporter type 1 deficiency syndrome (GLUT1-DS) who objected to or did not tolerate ketogenic diets.

Methods: We performed an open-label pilot study with three phases of 2 months each (baseline, treatment and withdrawal) in eight patients with GL...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2015-311475

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Publisher:
BMJ Publishing Group Publisher's website
Journal:
Journal of Neurology, Neurosurgery and Psychiatry Journal website
Volume:
87
Issue:
5
Pages:
550-553
Publication date:
2015-11-03
Acceptance date:
2015-10-14
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Pmid:
26536893

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