Journal article
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity
- Abstract:
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Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium falciparum. This activity translates into potent transmission-blocking potential, as shown by in vitro male gamete formation assays and...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 382.0KB)
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- Publisher copy:
- 10.1038/s41564-017-0007-4
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Authors
Funding
+ Bill and Melinda Gates Foundation
More from this funder
Funding agency for:
Winzeler, EA
Grant:
R01 AI103058
+ National Institutes of Health
More from this funder
Funding agency for:
Winzeler, EA
Grant:
R01 AI103058
+ National Institutes of Health
More from this funder
Funding agency for:
Egan, TJ
Grant:
R01 AI110329
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Microbiology Journal website
- Volume:
- 2
- Pages:
- 1403-1414
- Publication date:
- 2017-08-14
- Acceptance date:
- 2017-07-11
- DOI:
- ISSN:
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2058-5276
- Pmid:
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28808258
- Source identifiers:
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724243
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:724243
- UUID:
-
uuid:4c03a3f7-9309-42f4-b53f-ca2abcd97a7a
- Local pid:
- pubs:724243
- Deposit date:
- 2018-04-12
Terms of use
- Copyright holder:
- © Vanaerschot, et al
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/s41564-017-0007-4
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