Journal article
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity
- Abstract:
-
Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissible intra-erythrocytic forms of the malaria parasite Plasmodium falciparum. This activity translates into potent transmission-blocking potential, as shown by in vitro male gamete formation assays and...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
Actions
Access Document
- Files:
-
-
(pdf, 382.0KB)
-
- Publisher copy:
- 10.1038/s41564-017-0007-4
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Microbiology Journal website
- Volume:
- 2
- Pages:
- 1403-1414
- Publication date:
- 2017-08-14
- Acceptance date:
- 2017-07-11
- DOI:
- ISSN:
-
2058-5276
- Pubs id:
-
pubs:724243
- URN:
-
uri:4c03a3f7-9309-42f4-b53f-ca2abcd97a7a
- UUID:
-
uuid:4c03a3f7-9309-42f4-b53f-ca2abcd97a7a
- Local pid:
- pubs:724243
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- © Vanaerschot, et al
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/s41564-017-0007-4
If you are the owner of this record, you can report an update to it here: Report update to this record