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Unnatural amino acids as metal-mediated probes of biological function

Abstract:

Conjugation reactions on proteins have been used to access various post-translational modifications, for targeted delivery of drugs, for microscopy, and in studying receptor-ligand interactions. However, the ability to modify native proteins is constrained by the reactive functionalities of naturally occurring amino acids. This has driven research into the incorporation of unnatural amino acids (UAAs) into proteins. Research in this area has been motivated both by the possibility of increa...

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Institution:
University of Oxford
Research group:
Ben Davis Group
Oxford college:
St Edmund Hall
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
Role:
Author

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Supervisor
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Funding agency for:
Bhaskar Bhushan
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:4b1cbed6-1151-4b9f-ad97-aa5765cc9384
Local pid:
ora:10795

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