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The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells

Abstract:
Background: T follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such as transplant rejection and autoimmune diseases. We investigated the impact of the immunosuppressive agent tacrolimus on human Tfh cell differentiation and function in transplant recipients. Methods: Paired ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2018.01184

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Oxford college:
Green Templeton College
Role:
Author
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Grant:
FP7programme—The ONEStudy
BioDRIM
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
MAY
Article number:
1184
Publication date:
2018-05-31
Acceptance date:
2018-05-14
DOI:
ISSN:
1664-3224
Pmid:
29904381
Source identifiers:
856584
Language:
English
Keywords:
Pubs id:
pubs:856584
UUID:
uuid:4af2a172-3a11-4438-b75a-712c519a8a91
Local pid:
pubs:856584
Deposit date:
2018-08-14

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