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Journal article

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

Abstract:

Microbiome-wide association studies on large population cohorts have highlighted associations between the gut microbiome and complex traits, including type 2 diabetes (T2D) and obesity1. However, the causal relationships remain largely unresolved. We leveraged information from 952 normoglycemic individuals for whom genome-wide genotyping, gut metagenomic sequence and fecal short-chain fatty acid (SCFA) levels were available2, then combined this information with genome-wide-association summary...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-019-0350-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
51
Pages:
600-605
Publication date:
2019-02-18
Acceptance date:
2018-12-14
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
963674
Pubs id:
pubs:963674
UUID:
uuid:4a35177d-3dc5-4784-831e-9d500f1f878b
Local pid:
pubs:963674
Deposit date:
2019-01-18

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