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Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Abstract:

Defective DNA mismatch repair (dMMR) causes elevated tumour mutational burden (TMB) and microsatellite instability (MSI) in multiple cancer types. dMMR/MSI colorectal cancers (CRCs) have enhanced T cell infiltrate and favourable outcome, however this association has not been reliably detected in other tumour types, including endometrial cancer (EC). We sought to confirm this and explore the underpinning mechanisms. We first meta-analysed CRC and EC trials which have examined the prognostic va...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.5894

Authors


Publisher:
Wiley
Journal:
Journal of Pathology More from this journal
Volume:
257
Issue:
3
Pages:
340-351
Publication date:
2022-04-01
Acceptance date:
2022-03-07
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
1243143
Local pid:
pubs:1243143
Deposit date:
2022-03-10

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