Journal article
Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape
- Abstract:
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Defective DNA mismatch repair (dMMR) causes elevated tumour mutational burden (TMB) and microsatellite instability (MSI) in multiple cancer types. dMMR/MSI colorectal cancers (CRCs) have enhanced T cell infiltrate and favourable outcome, however this association has not been reliably detected in other tumour types, including endometrial cancer (EC). We sought to confirm this and explore the underpinning mechanisms. We first meta-analysed CRC and EC trials which have examined the prognostic va...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 19.8MB, Terms of use)
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- Publisher copy:
- 10.1002/path.5894
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Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Journal of Pathology More from this journal
- Volume:
- 257
- Issue:
- 3
- Pages:
- 340-351
- Publication date:
- 2022-04-01
- Acceptance date:
- 2022-03-07
- DOI:
- EISSN:
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1096-9896
- ISSN:
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0022-3417
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1243143
- Local pid:
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pubs:1243143
- Deposit date:
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2022-03-10
Terms of use
- Copyright holder:
- Glaire et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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