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Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil

Abstract:

Several COVID-19 vaccines have shown good efficacy in clinical trials, but there remains uncertainty about the efficacy of vaccines against different variants. Here, we investigate the efficacy of ChAdOx1 nCoV-19 (AZD1222) against symptomatic COVID-19 in a post-hoc exploratory analysis of a Phase 3 randomised trial in Brazil (trial registration ISRCTN89951424). Nose and throat swabs were tested by PCR in symptomatic participants. Sequencing and genotyping of swabs were performed to determine ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-25982-w

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-5330-0240
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Contributors

Role:
Contributor
Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Article number:
5861
Publication date:
2021-10-06
Acceptance date:
2021-09-13
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1186587
Local pid:
pubs:1186587
Deposit date:
2021-10-12

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