Journal article
Chronic TNFα - driven injury delays cell migration to villi in the intestinal epithelium
- Abstract:
-
The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in invaginations called crypts, and by crypt cell migration onto protrusions called villi; dysregulation of such mechanisms may render the gut susceptible to chronic in ammation. The impact that excessive or misplaced epithelial cell death may have on villus ce...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
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- Files:
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(pdf, 4.3MB)
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- Publisher copy:
- 10.1098/rsif.2018.0037
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Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Interface Journal website
- Volume:
- 15
- Issue:
- 145
- Pages:
- Article: 20180037
- Publication date:
- 2018-08-01
- Acceptance date:
- 2018-07-03
- DOI:
- EISSN:
-
1742-5662
- ISSN:
-
1742-5689
- Pubs id:
-
pubs:864655
- URN:
-
uri:487ede2f-9c04-4344-b4b7-3a153c68cecd
- UUID:
-
uuid:487ede2f-9c04-4344-b4b7-3a153c68cecd
- Local pid:
- pubs:864655
Terms of use
- Copyright holder:
- © 2018 Daniele, et al
- Copyright date:
- 2018
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Royal Society at: 10.1098/rsif.2018.0037
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