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Journal article

Chronic TNFα - driven injury delays cell migration to villi in the intestinal epithelium

Abstract:

The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in invaginations called crypts, and by crypt cell migration onto protrusions called villi; dysregulation of such mechanisms may render the gut susceptible to chronic in ammation. The impact that excessive or misplaced epithelial cell death may have on villus ce...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2018.0037

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Mathematical Institute
Role:
Author
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Publisher:
Royal Society Publisher's website
Journal:
Interface Journal website
Volume:
15
Issue:
145
Article number:
20180037
Publication date:
2018-08-01
Acceptance date:
2018-07-03
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Source identifiers:
864655
Pubs id:
pubs:864655
UUID:
uuid:487ede2f-9c04-4344-b4b7-3a153c68cecd
Local pid:
pubs:864655
Deposit date:
2018-07-06

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