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Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group).

Abstract:

OBJECTIVES: Over the last 20 years a number of small trials have reported that spironolactone effectively prevents acute mountain sickness (AMS), but to date there have been no large randomized trials investigating the efficacy of spironolactone in prevention of AMS. Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS. METHODS: Participants were sampled from a diverse population of western ...

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Publisher copy:
10.1016/j.wem.2010.10.009

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Journal:
Wilderness and environmental medicine
Volume:
22
Issue:
1
Pages:
15-22
Publication date:
2011-03-01
DOI:
EISSN:
1545-1534
ISSN:
1080-6032
Source identifiers:
127412
Language:
English
Keywords:
Pubs id:
pubs:127412
UUID:
uuid:47d44cc7-8f04-4377-a0bd-ce0d6b2be965
Local pid:
pubs:127412
Deposit date:
2012-12-19

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