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Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease

Abstract:

Background Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigenetic changes and IBD. Independent GWA studies have identified genetic variants in the BACH2, IL6ST, LAMB1, IKZF1, and MGAT3 loci to be associated with both IBD and immunoglobulin G (IgG) glycosylation.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13148-018-0507-y

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Funding agency for:
Satsangi, J
Grant:
Seventh Framework Programme: 305479
Publisher:
BioMed Central Publisher's website
Journal:
Clinical Epigenetics Journal website
Volume:
10
Issue:
1
Pages:
75
Publication date:
2018-06-04
Acceptance date:
2018-05-22
DOI:
EISSN:
1868-7083
ISSN:
1868-7075
Pmid:
29991969
Source identifiers:
857714
Language:
English
Pubs id:
pubs:857714
UUID:
uuid:473b0d21-2c82-4519-9e84-1e55b43d5a78
Local pid:
pubs:857714
Deposit date:
2018-12-01

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