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Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multicohort multivariable regression and Mendelian randomization analyses

Abstract:

Background: Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk. We combined adjusted multivariable regression (AMV) and MR analyses of phenotypes of unfavourable sleep on 113 metabolomic traits to investigate possible biochemical mechanisms linking sleep to cardiovascular disease.

Methods: We...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12916-021-01939-0

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Oxford college:
Wolfson College
Role:
Author
More by this author
Oxford college:
Wolfson College
Role:
Author
More by this author
Oxford college:
Wolfson College
Role:
Author
More by this author
Oxford college:
Wolfson College
Role:
Author
More by this author
Oxford college:
Wolfson College
Role:
Author
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Publisher:
BMC Publisher's website
Journal:
BMC Medicine Journal website
Volume:
19
Issue:
2021
Article number:
69
Publication date:
2021-03-18
Acceptance date:
2021-02-11
DOI:
EISSN:
1741-7015
Language:
English
Keywords:
Pubs id:
1161981
Local pid:
pubs:1161981
Deposit date:
2021-02-17

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