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Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model

Abstract:

Background

Radiotherapy enhances innate and adaptive anti-tumour immunity. It is unclear whether this effect may be harnessed by combining immunotherapy with radiotherapy fractions used to treat prostate cancer. We investigated tumour immune microenvironment responses of pre-clinical prostate cancer models to radiotherapy. Having defined this landscape, we tested whether radiotherapy-induced tumour growth delay could be enhanced with anti-PD-L1.

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41416-020-0956-x

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0003-1948-6779
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author
ORCID:
0000-0002-0291-7117
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
123
Pages:
1089–1100
Publication date:
2020-07-09
Acceptance date:
2020-06-04
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
1117260
Local pid:
pubs:1117260
Deposit date:
2020-07-09

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