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Journal article

Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvessels

Abstract:

Circulating extracellular vesicles (EVs) regulate signaling pathways via receptor-ligand interactions and content delivery, after attachment or internalization by endothelial cells. However, they originate from diverse cell populations and are heterogeneous in composition. To determine the effects of specific surface molecules, the use of synthetic EV mimetics permits the study of specific EV receptor-ligand interactions. Here, we used endogenous EVs derived from the circulation of rats, as w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-019-52127-3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-5623-5568
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Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
9
Issue:
1
Article number:
15847
Publication date:
2019-11-01
Acceptance date:
2019-10-14
DOI:
EISSN:
2045-2322
Pmid:
31676801
Source identifiers:
1069870
Language:
English
Keywords:
Pubs id:
pubs:1069870
UUID:
uuid:46640e3d-7d1c-4039-9785-9fa91b8a82b8
Local pid:
pubs:1069870
Deposit date:
2019-11-08

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