Journal article
Memory inflation following adenoviral vaccination depends on IL-21
- Abstract:
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Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed “memory inflation”. During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination can induce phenotypically, functionally and transcriptionally similar inflationary responses, but it is not known how IL-21 influences the inflating memory response to adenoviral...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 645.7KB)
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- Publisher copy:
- 10.1016/j.vaccine.2018.09.061
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Authors
Funding
+ National Institutes of Health
More from this funder
Funding agency for:
Hutchings, C
Grant:
U19AI 082630
+ Oxford University Returning Carers Fund
More from this funder
Funding agency for:
Hutchings, C
Grant:
U19AI 082630
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Vaccine Journal website
- Volume:
- 36
- Issue:
- 46
- Pages:
- 7011-7016
- Publication date:
- 2018-09-29
- Acceptance date:
- 2018-09-25
- DOI:
- EISSN:
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1873-2518
- ISSN:
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0264-410X
- Pmid:
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30279090
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:923870
- UUID:
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uuid:464ec3e0-f5d5-4b15-a511-cde2eca976a4
- Local pid:
- pubs:923870
- Deposit date:
- 2018-10-17
Terms of use
- Copyright holder:
- Gordon et al
- Copyright date:
- 2018
- Notes:
-
© 2018 The Authors. Published by Elsevier Ltd. This is an open access
article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
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