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Journal article

Memory inflation following adenoviral vaccination depends on IL-21

Abstract:

Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed “memory inflation”. During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination can induce phenotypically, functionally and transcriptionally similar inflationary responses, but it is not known how IL-21 influences the inflating memory response to adenoviral...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2018.09.061

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Experimental Medicine
Role:
Author
ORCID:
0000-0002-3337-2455
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Experimental Medicine
Role:
Author
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Funding agency for:
Hutchings, C
Grant:
U19AI 082630
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Funding agency for:
Hutchings, C
Grant:
U19AI 082630
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Funding agency for:
Hutchings, C
Grant:
U19AI 082630
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Funding agency for:
Provine, N
Grant:
Postdoctoral Fellowship
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Funding agency for:
Klenerman, P
Grant:
109965MA
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
36
Issue:
46
Pages:
7011-7016
Publication date:
2018-09-29
Acceptance date:
2018-09-25
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pmid:
30279090
Language:
English
Keywords:
Pubs id:
pubs:923870
UUID:
uuid:464ec3e0-f5d5-4b15-a511-cde2eca976a4
Local pid:
pubs:923870
Deposit date:
2018-10-17

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