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A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

Abstract:

OBJECTIVE: To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. METHODS: We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and approximately 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values <1 x 10(-7) considered genome-wide signif...

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Publication status:
Published

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Publisher copy:
10.1002/art.27184

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Journal:
Arthritis and rheumatism
Volume:
62
Issue:
2
Pages:
499-510
Publication date:
2010-02-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Source identifiers:
107316

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