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Chemical and biological studies on human oxygenases

Abstract:

As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development ...

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Institution:
University of Oxford
Research group:
Prof. Christopher J. Schofield
Oxford college:
Brasenose College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology
Role:
Author

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Funding agency for:
Cyrille Christophe Thinnes
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:455f2e65-f294-461b-b44f-cd53796b14a0
Local pid:
ora:11301

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