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Journal article

Insights from deep sequencing of the HBV genome — Unique, tiny, and misunderstood

Abstract:

Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection, which causes 0.8 million deaths a year. Due to the high burden of disease, international health agencies have set the goal of eliminating HBV infe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1053/j.gastro.2018.07.058

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Target Discovery Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM Experimental Medicine
Role:
Author
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More from this funder
Funding agency for:
McKeating, J
Grant:
IA 200838/Z/16/Z
More from this funder
Funding agency for:
McKeating, J
Grant:
IA 200838/Z/16/Z
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Funding agency for:
Matthews, P
Grant:
110110
Publisher:
Elsevier Publisher's website
Journal:
Gastroenterology Journal website
Volume:
156
Issue:
2
Pages:
384-399
Publication date:
2018-09-27
Acceptance date:
2018-07-23
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Source identifiers:
905672
Pubs id:
pubs:905672
UUID:
uuid:453afce9-8a90-4b3f-b940-07d010b447f7
Local pid:
pubs:905672
Deposit date:
2018-08-14

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