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Clinical implications of Plasmodium resistance to atovaquone/proguanil: a systematic review and meta-analysis

Abstract:

Background: Atovaquone/proguanil, registered as Malarone®, is a fixed-dose combination recommended for first-line treatment of uncomplicated Plasmodium falciparum malaria in non-endemic countries and its prevention in travellers. Mutations in the cytochrome bc1 complex are causally associated with atovaquone resistance. Methods: This systematic review assesses the clinical efficacy of atovaquone/proguanil treatment of uncomplicated malaria and examines the extent to which codon 268 mutation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/jac/dkx431

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Kellogg College
Role:
Author
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Grant:
SeventhFramework Programmeundergrantagreement304948—NanoMal(toS.K.
H.M.S
Publisher:
Oxford University Press Publisher's website
Journal:
Journal Of Antimicrobial Chemotherapy Journal website
Volume:
73
Issue:
3
Pages:
581–595
Publication date:
2017-12-11
Acceptance date:
2017-10-23
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Source identifiers:
821105
Pubs id:
pubs:821105
UUID:
uuid:4406b8e4-98ca-4b06-bf6e-b4c46e042b46
Local pid:
pubs:821105
Deposit date:
2018-01-24

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